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Invitrogen
Dengue Virus Type 2/4 NS4B (Thailand/16681/1984) Recombinant Rabbit Monoclonal Antibody (HL3134)
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Dengue Virus Type 2/4 NS4B (Thailand/16681/1984) Antibody (MA5-56677) in WB
Western Blot analysis of Dengue Virus Type 2/4 NS4B (Thailand/16681/1984) using Dengue Virus Type 2/4 NS4B (Thailand/16681/1984) Recombinant Monoclonal Antibody (Product # MA5-56677). Non-infected and infected BHK-21 whole cell extracts were separated by 12% SDS-PAGE, and the membrane was blotted with Dengue Virus Type 2/4 NS4B (Thailand/16681/1984) antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit ... View More
产品信息
MA5-56677
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL3134
抗原
Full length of Dengue virus NS4B protein. (strain# Thailand/16681/1984)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
The Dengue Virus Type 2/4 NS4B protein is a non-structural protein that plays a critical role in the replication and pathogenesis of the dengue virus, specifically in serotypes 2 and 4 (DENV-2 and DENV-4). NS4B is a hydrophobic protein that is integrated into the host cell's endoplasmic reticulum membrane, where it contributes to the formation of the viral replication complex. This complex is essential for the synthesis of viral RNA, thereby facilitating the production of new viral particles. NS4B interacts with other non-structural proteins such as NS3 and NS5, and it also plays a role in modulating the host's immune response, helping the virus to evade detection and destruction by the host's immune system. Dengue virus is transmitted to humans primarily through Aedes mosquitoes and causes dengue fever, which can range from mild to severe. Symptoms include high fever, severe headache, retro-orbital pain, joint and muscle pain, rash, and in severe cases, hemorrhagic manifestations or dengue shock syndrome. Due to its essential functions in the viral life cycle and its role in immune evasion, NS4B represents an important target for antiviral drug development. Understanding the structure and function of the NS4B protein in both DENV-2 and DENV-4 serotypes is crucial for designing effective antiviral therapies and for advancing our knowledge of dengue virus biology and pathogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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