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NeoBiotechnologies
Desmocollin-2/3 Monoclonal Antibody (rDSC2/3437)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
1824-MSM2-P0
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
rDSC2/3437
抗原
Recombinant full-length human DSC2 protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
200 µg/mL
规格
20 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARVC10; ARVD10; cadherin family member 2; cadherin family member 3; CDHF5; CDHF6; CMD1BB; desmocollin-4; desmoglein-2; desmoglein-3; desmosomal cadherin; desmosomal glycoprotein II/III; desmosomal protein; epithelial type 2 desmocollin; HDGC; MDSC3a; PVA; unnamed protein product
基因别名: 5430426I24Rik; ARVD11; CDHF2; CDHF3; DG2; DGII/III; DSC; DSC1; DSC2; DSC3; DSC4; HT-CP
UniProt ID: (Human) Q02487, (Human) Q14574, (Mouse) P55292, (Mouse) P55850
Entrez Gene ID: (Human) 1824, (Human) 1825, (Mouse) 13506, (Rat) 291760, (Rat) 307563, (Mouse) 13507
in utero embryonic development
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
synapse assembly
regulation of axonogenesis
protein stabilization
cell-cell adhesion
cellular response to starvation
cardiac muscle cell-cardiac muscle cell adhesion
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
epithelial cell-cell adhesion
positive regulation of wound healing
regulation of ventricular cardiac muscle cell action potential
positive regulation of p38MAPK cascade
positive regulation of cellular protein localization
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