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Invitrogen
Desmoglein 3 Recombinant Mouse Monoclonal Antibody (AK23)
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Desmoglein 3 Antibody (MA5-51877) in ICC/IF
Immunocytochemistry analysis of Desmoglein 3 in paraformaldehyde fixed A431 cells using Desmoglein 3 Recombinant Mouse Monoclocal Antibody (Product # MA5-51877) at a 1:100 dilution for 1h followed by Alexa Fluor 488 secondary antibody (1:1,000 dilution), showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom: primary antibody, DAPI, merged channels and an isotyp... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-51877
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
AK23
抗原
The original antibody was generated by immunizing Dsg3 knockout mice with recombinant mouse Dsg3-His in complete Freund's adjuvant subcutaneously.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
200 µg
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody binds mouse Dsg3 and also shows reactivity for human Dsg3. It does not show any affinity towards Dsg1. AK23 recognizes a calcium-dependent conformational epitope on Dsg3, which consisted of the V3, K7, P8, and D59 Dsg3-specific residues that formed the adhesive interface between juxtaposed Dsg.
靶标信息
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 130 kDa pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen homolog; cadherin family member 6; DKFZp686P23184; unnamed protein product
基因别名: ABOLM; bal; CDHF6; PVA
UniProt ID: (Human) P32926, (Mouse) O35902
Entrez Gene ID: (Human) 1830, (Mouse) 13512
desmosome assembly
actin filament organization
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell migration
regulation of protein stability
adherens junction assembly
cell-cell adhesion
tight junction assembly
positive regulation of bicellular tight junction assembly
negative regulation of p38MAPK cascade
positive regulation of protein localization to adherens junction
positive regulation of protein localization to membrane
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