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产品信息
PA5-142165
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence QDKSNTDKWEKDEMTKDC.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2932823
产品详细信息
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:2,000.
靶标信息
Dicer is a double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. It cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a means to specifically regulate the expression of target genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DCR; DCR-1; dicer 1 ribonuclease III; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease type III; Dicer1, Dcr-1 homolog; Endoribonuclease Dicer; Helicase MOI; Helicase with RNase motif; helicase-moi
基因别名: DCR1; DICER; DICER1; Dicer1e; HERNA; K12H4.8-LIKE; KIAA0928; MNG1; RMSE2
UniProt ID: (Human) Q9UPY3
Entrez Gene ID: (Human) 23405
negative regulation of transcription from RNA polymerase II promoter
apoptotic DNA fragmentation
negative regulation of Schwann cell proliferation
positive regulation of Schwann cell differentiation
nerve development
production of siRNA involved in RNA interference
targeting of mRNA for destruction involved in RNA interference
gene silencing by RNA
pre-miRNA processing
positive regulation of myelination
peripheral nervous system myelin formation
conversion of ds siRNA to ss siRNA involved in RNA interference
siRNA loading onto RISC involved in RNA interference
production of miRNAs involved in gene silencing by miRNA
miRNA loading onto RISC involved in gene silencing by miRNA
conversion of ds siRNA to ss siRNA
neuron projection morphogenesis
RNA phosphodiester bond hydrolysis, endonucleolytic
