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Invitrogen
Diphenhydramine Recombinant Mouse Monoclonal Antibody (1A10)
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Diphenhydramine Antibody (MA566537) in SDS-PAGE
SDS-PAGE characterization of Diphenhydramine under reducing conditions. Lane M: Protein marker (kDa); Lane DPHD: Purified Diphenhydramine Recombinant Monoclonal (Product # MA566537). Diphenhydramine showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-640.
产品信息
MA566537
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1A10
抗原
Conjugate of DPHD hapten and KLH.
偶联物
形式
Liquid
浓度
1.4 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Diphenhydramine is a first-generation antihistamine commonly used to manage allergic disorders, insomnia, pruritus, urticaria, vertigo, motion sickness, and dystonias. It functions by competitively antagonizing histamine at the H1 receptor, providing relief from allergic symptoms. Diphenhydramine is metabolized primarily by cytochrome P450 isozymes in the liver, specifically involving N-demethylation processes. Structurally, it belongs to the ethanolamine class of antihistamines, characterized by dimethylaminoethylbenzhydryl ethers with various substitutions. This compound is widely available in over-the-counter medications due to its sedative properties, although paradoxical excitation can occur in some individuals. Its gene location and specific metabolic pathways are still under investigation, with studies focusing on its interaction with human liver microsomes and recombinant P450 isozymes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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