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Invitrogen
Diphtheria Toxin Polyclonal Antibody
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产品信息
PA1-7212
产品规格
种属反应
Bacteria
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Purified diphtheria toxoid.
偶联物
形式
Liquid
浓度
5.0 mg/mL
纯化类型
IgG fraction
保存液
PBS, pH 7.2
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-7212 detects diphtheria toxin.
PA1-7212 has been successfully used in ELISA procedures.
The PA1-7212 immunogen is purified diphtheria toxoid.
For longer term storage, aliquot and freeze at -20°C.
靶标信息
Diphtheria toxin is a 58 kDa protein secreted by lysogenic strains of Corynebacterium diphtheriae. The toxin causes the disease diphtheria in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis. The mechanism of inhibition involves transfer of the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive. The catalysed reaction is as follows: NAD + + peptide diphthamide = nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide The crystal structure of the diphtheria toxin homodimer has been determined to 2.5A resolution. The structure reveals a Y-shaped molecule of 3 domains, a catalytic domain (fragment A), whose fold is of the alpha + beta type; a transmembrane (TM) domain, which consists of 9 alpha-helices, 2 pairs of which may participate in pH-triggered membrane insertion and translocation; and a receptor-binding domain, which forms a flattened beta-barrel with a jelly-roll-like topology. The TM- and receptor binding-domains together constitute fragment B.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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