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Invitrogen
Dynactin 2 Polyclonal Antibody
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图: 1 / 2
Dynactin 2 Antibody (PA5-47881) in ICC/IF
Immunocytochemistry analysis of Dynactin 2 in immersion fixed HeLa human cervical epithelial carcinoma cell line. Samples were incubated in Dynactin 2 polyclonal antibody (Product # PA5-47881) using a dilution of 15 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to c... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-47881
产品规格
种属反应
Human,
Mouse
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human Dynactin Subunit 2/DCTN2 Asp277-Lys401
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody detects human Dynactin Subunit 2/DCTN2 in direct ELISAs and human and mouse Dynactin Subunit 2/DCTN2 in Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human DCTN1 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 50 kDa dynein-associated polypeptide; DCTN-50; Dynactin complex 50 kDa subunit; Dynactin subunit 2; GMP23-48K; Growth cone membrane protein 23-48K; p50 dynamitin
基因别名: 2310042E05Rik; C130077D06Rik; C87049; DCTN-50; DCTN2; DCTN50; GMP23-48K; p50; RBP50
UniProt ID: (Mouse) Q99KJ8
Entrez Gene ID: (Mouse) 69654
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