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Invitrogen
Dynein Polyclonal Antibody
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Dynein Antibody (PA5-89506) in WB
Western blot analysis of Dynein in extracts of various cell lines. Samples were incubated with Dynein Polyclonal antibody (Product # PA5-89506) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-89506
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-89 of human DYNLL2 (NP_5424081)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.18 mg/mL
规格
18 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MSDRKAVIKN ADMSEDMQQD AVDCATQAME KYNIEKDIAA YIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG; Positive Samples: Mouse brain, Mouse kideny, Rat brain; Cellular Location: Cytoplasm, cytoskeleton
靶标信息
The directed movement of membrane-bounded organelles is an important process for various cellular functions including membrane transport, secretion, and axonal transport. Cytoplasmic dynein, a ubiquitous minus end-directed microtubule-based motor protein, is believed to be responsible for the retrograde transport of membranous organelles from the synapse to the cell body in fast axonal transport. The cytoplasmic dynein complex is composed of two ~530 kDa heavy chains, and intermediate chains of ~74 kDa and ~53-59 kDa.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 8 kDa dynein light chain; 8 kDa dynein light chain b; 8kD LC; 8kDa LC; cytosolic DH IC-1; DLC8; dynein LC8; Dynein light chain 1, cytoplasmic; Dynein light chain 2, cytoplasmic; Dynein light chain LC8-type 1; Dynein light chain LC8-type 2; dynein light chain-2; dynein, cytoplasmic, light chain 1; dynein, cytoplasmic, light peptide; mPIN; PIN; Protein inhibitor of neuronal nitric oxide synthase; protein inhibitor of nitric oxide synthase
基因别名: 1700064A15Rik; 6720463E02Rik; 8kDLC; C87222; Dlc1; Dlc2; DLC8; DLC8b; Dncl1; Dnclc1; Dynll1; Dynll2; Pin
UniProt ID: (Rat) P63170, (Mouse) P63168, (Rat) Q78P75, (Mouse) Q9D0M5
Entrez Gene ID: (Rat) 58945, (Mouse) 56455, (Rat) 140734, (Mouse) 68097
transcription, DNA-templated
regulation of transcription, DNA-templated
nitric oxide biosynthetic process
transport
apoptotic process
microtubule-based process
substantia nigra development
neurotransmitter metabolic process
negative regulation of phosphorylation
negative regulation of catalytic activity
regulation of catalytic activity
microtubule-based movement
intraciliary retrograde transport
negative regulation of nitric oxide biosynthetic process
cilium morphogenesis
synaptic target recognition
metabolic process
intracellular transport
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