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Dystrophin Polyclonal Antibody, Biotin

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Dystrophin Polyclonal Antibody, Biotin

产品信息

DMD-BIOTIN

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

酶联免疫吸附实验 (ELISA)

1:10,000
-

免疫沉淀 (IP)

1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acids within region 1-50 on human Dystrophin protein.
3D表位/免疫原

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 µg/mL

纯化类型

Antigen affinity chromatography

保存液

proprietary buffer with 30% glycerol

内含物

0.01% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immunohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: apodystrophin-3; apodystrophin-I; DMD; Dpm234; Duchenne muscular dystrophy (DMD); dystrophin; dystrophin delta-E40e; dystrophin Dp427-E40e; dystrophin Dp71d(delta71,73-74); dystrophin Dp71f-delta71,74; dystrophin E40e; dystrophin E51b; dystrophin, muscular dystrophy; dystrophin-related; GS1-19O24.1; Muscular dystrophy Duchenne and Becker types; mutant dystrophin; OTTHUMP00000215592; unnamed protein product; X-linked muscular dystrophy

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基因别名: BMD; CMD3B; DNADMD1; Dp427; Dp71; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; DXSmh7; DXSmh9; dys; mdx; MRX85; pke

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UniProt ID: (Human) P11532, (Rat) P11530, (Mouse) P11531

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Entrez Gene ID: (Human) 1756, (Rat) 24907, (Mouse) 13405

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功能
dystroglycan binding actin binding integrin binding structural constituent of cytoskeleton protein binding lamin binding zinc ion binding structural constituent of muscle myosin binding vinculin binding PDZ domain binding macromolecular complex binding nitric-oxide synthase binding
参与通路
positive regulation of cell-matrix adhesion regulation of heart rate regulation of transcription, DNA-templated apoptotic process striated muscle contraction inflammatory response muscle organ development skeletal muscle tissue development establishment of blood-nerve barrier protein localization positive regulation of cell proliferation determination of adult lifespan response to xenobiotic stimulus gene expression regulation of gene expression regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of neuron projection development regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of skeletal muscle contraction response to denervation involved in regulation of muscle adaptation myotube cell development olfactory nerve structural organization cerebral cortex development cell differentiation neuron differentiation multicellular organism growth response to muscle stretch regulation of membrane potential muscle cell differentiation peptide biosynthetic process skeletal muscle tissue regeneration negative regulation of neuron differentiation positive regulation of neuron differentiation muscle cell cellular homeostasis neuron development neuron projection morphogenesis nucleus localization muscle cell development striated muscle cell development cardiac muscle contraction limb development bone development establishment of glial blood-brain barrier connective tissue development protein-containing complex assembly negative regulation of ERK1 and ERK2 cascade cardiac muscle cell action potential regulation of muscle system process regulation of cellular response to growth factor stimulus walking behavior synaptic signaling regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport reactive oxygen species biosynthetic process muscle contraction cytoskeleton organization maintenance of blood-brain barrier camera-type eye development regulation of system process motile cilium assembly
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