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Invitrogen
E2F6 Recombinant Rabbit Monoclonal Antibody (9I5M0)
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E2F6 Antibody (MA5-37840) in WB
Western blot analysis of E2F6 in extracts of various cell lines. Samples were incubated with E2F6 Monoclonal antibody (Product # MA5-37840) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
MA5-37840
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
9I5M0
抗原
Recombinant Protein (or fragment)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: 293T, HepG2, RD
Immunogen sequence: LDGIDLVEKK SKNHIRWIGS DLSNFGAVPQ QKKLQEELSD LSAMEDALDE LIKDCAQQLF ELTDDKENER LAYVTYQDIH SIQAFHEQIV IAVKAPAETR LDVPAPREDS ITVHIRSTNG PIDVYLCEVE QGQTSNKRSE GVGTSSSEST HPEGPEEEEN PQQSEELLEV SN
靶标信息
This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E2F-6; MGC111545; Transcription factor E2F6
基因别名: E2F-6; E2F6
UniProt ID: (Human) O75461
Entrez Gene ID: (Human) 1876
