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Invitrogen
EAAC1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-140233
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.6 mg/mL
规格
60 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: FGTGIVEKLS KKELEQMDVS SEVNIVNPFA LESTILDNED SDTKKSYVNG GFAVDKSDTI SFTQTSQ
Highest antigen sequence indentity to the following orthologs: Mouse - 97%, Rat - 96%.
靶标信息
L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters. Four glutamate transporters have been identified: the sodium-dependent GLAST-1, GLT-1, EAAC-1 and the chloride-dependent EAAT-4. EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters are believed to include eight membrane-spanning alpha-helices and a loop-pore structure which is unique among secondary transporters but may resemble loop-pores found in ion channels. A second distinctive structural feature is the presence of a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane. Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity although no neurodegeneration was observed over a period of 12 months.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: excitatory amino acid carrier 1; neuronal and epithelial glutamate transporter; sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; unnamed protein product
基因别名: DCBXA; EAAC1; EAAT3; hEAAC1; SCZD18
UniProt ID: (Human) P43005
Entrez Gene ID: (Human) 6505
anion channel activity
L-glutamate transmembrane transporter activity
high-affinity glutamate transmembrane transporter activity
protein binding
chloride transmembrane transporter activity
L-aspartate transmembrane transporter activity
symporter activity
glutamate:sodium symporter activity
cysteine transmembrane transporter activity
identical protein binding
D-aspartate transmembrane transporter activity
response to amphetamine
regulation of heart rate
glutathione biosynthetic process
superoxide metabolic process
neurotransmitter transport
amino acid transport
cellular zinc ion homeostasis
dopamine receptor signaling pathway
glutamate receptor signaling pathway
chemical synaptic transmission
brain development
memory
grooming behavior
locomotory behavior
positive regulation of heart rate
gene expression
L-glutamate transport
cytokine-mediated signaling pathway
neurogenesis
adult behavior
maintenance of blood-brain barrier
exploration behavior
dopamine metabolic process
cysteine transport
response to morphine
negative regulation of neuron apoptotic process
blood vessel morphogenesis
synapse organization
neuron apoptotic process
L-glutamate import
retina development in camera-type eye
motor behavior
transepithelial transport
D-aspartate transmembrane transport
L-aspartate transmembrane transport
D-aspartate import
cellular response to cocaine
zinc II ion transmembrane transport
import into cell
L-glutamate import across plasma membrane
postsynaptic modulation of chemical synaptic transmission
L-aspartate import across plasma membrane
transport across blood-brain barrier
chloride transmembrane transport
cysteine transmembrane transport
conditioned place preference
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