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EAAC1 Monoclonal Antibody (N180/41), PerCP

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EAAC1 Monoclonal Antibody (N180/41), PerCP

产品信息

MA5-45549

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫细胞化学 (ICC/IF)

1:100
-

免疫沉淀 (IP)

Assay-dependent
-
产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

N180/41

抗原

Fusion protein amino acids 1-524 (full length) of human EAAC1
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偶联物

PerCP PerCP PerCP

激发/发射光谱

482/675 nm 查看光谱 spectra

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

95.64mM phosphate/2.48mM MES, pH 7.4, with 0.5M EDTA

内含物

no preservative

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2932003

产品详细信息

5 µg of MA5-45549 was sufficient for immunoprecipitation of EAAC1 from 50 µg of rat brain lysate.|Detects approximately 60kDa.

This antibody was formerly sold as clone S180-41.

靶标信息

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous systems. To maintain glutamate levels below excitoxic levels, excess glutamate at excitatory synaptic clefts is removed by ion-coupled glutamate transporters. Four glutamate transporters have been identified: the sodium-dependent GLAST-1, GLT-1, EAAC-1 and the chloride-dependent EAAT-4. EAAC-1 is expressed in the CNS and also found in kidney and small intestine. Structural features of glutamate transporters are believed to include eight membrane-spanning alpha-helices and a loop-pore structure which is unique among secondary transporters but may resemble loop-pores found in ion channels. A second distinctive structural feature is the presence of a highly amphipathic membrane-spanning helix that provides a hydrophilic path through the membrane. Mice with homozygous deletions of the EAAC-1 transporter gene develop dicarboxylic aminoaciduria and display reduced spontaneous locomotor activity although no neurodegeneration was observed over a period of 12 months.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: excitatory amino acid carrier 1; Excitatory amino acid transporter 3; excitatory amino acid transporter-3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 A1 (brain glutamate transporter); Solute carrier family 1 member 1; solute carrier family 1, member 1; unnamed protein product

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基因别名: DCBXA; EAAC1; EAAT3; HEAAC1; REAAC1; SCZD18; SLC1A1

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UniProt ID: (Human) P43005, (Rat) P51907

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Entrez Gene ID: (Human) 6505, (Rat) 25550

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功能
anion channel activity L-glutamate transmembrane transporter activity high-affinity glutamate transmembrane transporter activity protein binding chloride transmembrane transporter activity L-aspartate transmembrane transporter activity symporter activity glutamate:sodium symporter activity cysteine transmembrane transporter activity identical protein binding metal ion binding D-aspartate transmembrane transporter activity glutamate binding sodium:dicarboxylate symporter activity primary active transporter
参与通路
behavioral fear response response to amphetamine regulation of heart rate glutathione metabolic process glutathione biosynthetic process superoxide metabolic process ion transport neurotransmitter transport amino acid transport cellular zinc ion homeostasis dopamine receptor signaling pathway glutamate receptor signaling pathway chemical synaptic transmission brain development learning or memory memory grooming behavior locomotory behavior response to xenobiotic stimulus positive regulation of heart rate gene expression retina layer formation L-glutamate transport cytokine-mediated signaling pathway neurogenesis adult behavior cellular response to oxidative stress maintenance of blood-brain barrier response to decreased oxygen levels dopamine metabolic process cysteine transport response to morphine negative regulation of neuron apoptotic process establishment of protein localization blood vessel morphogenesis response to axon injury synapse organization neuron apoptotic process L-glutamate import righting reflex retina development in camera-type eye heart contraction long-term synaptic potentiation motor behavior transepithelial transport D-aspartate transmembrane transport L-aspartate transmembrane transport D-aspartate import cellular response to ammonium ion cellular response to mercury ion cellular response to cocaine zinc II ion transmembrane transport response to anesthetic regulation of protein targeting to membrane glutamate homeostasis motor neuron apoptotic process import into cell L-glutamate import across plasma membrane neurotransmitter receptor transport to plasma membrane postsynaptic modulation of chemical synaptic transmission L-aspartate import across plasma membrane transport across blood-brain barrier chloride transmembrane transport cysteine transmembrane transport cellular response to bisphenol A conditioned place preference sodium ion transmembrane transport protein homooligomerization L-glutamate transmembrane transport
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