Search
Fabgennix
EAAT2 Polyclonal Antibody, Biotin
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
SLC1A-BIOTIN
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to C terminal amino acids 550-574 of Human EAAT2. Sequence:KVTLAANGKSADCSVEEEPWKREK
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Excitatory amino acid transporter 2 (EAAT2) is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis (ALS.) Alternatively spliced transcript variants of this gene have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: alternatively spliced; EAAT2; EAAT2 variant mEAAT2/5UT2; EAAT2 variant mEAAT2/5UT5; excitotoxic amino acid transporter 2; glial glutamate transporter GLT1/V1; glial glutamate transporter GLT1/V2; glial glutamate transporter GLT1/V3; glial glutamate transporter GLT1/V4; GLT1 variant; transmembrane glycoprotein; GLT1a; GLT1b; GLT1c; glutamate transporter 1; glutamate transporter 1c; glutamate transporter-1; glutamate/aspartate transporter II; high affinity glucose transporter; human brain glutamate transporter; mGLT-1; mGLT-1A; mGLT-1B; OTTHUMP00000165209; OTTHUMP00000165210; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; solute carrier family 1, member 2; unnamed protein product
Gene Aliases: 1700091C19Rik; 2900019G14Rik; DEE41; EAAT2; EIEE41; Glt; GLT-1; GLT1; HBGT; MGLT1
UniProt ID: (Human) P43004, (Mouse) P43006, (Rat) P31596
Entrez Gene ID: (Human) 6506, (Mouse) 20511, (Rat) 29482
L-glutamate transmembrane transporter activity
high-affinity glutamate transmembrane transporter activity
protein binding
anion transmembrane transporter activity
neutral amino acid transmembrane transporter activity
symporter activity
glutamate:sodium symporter activity
cysteine transmembrane transporter activity
glutathione biosynthetic process
nervous system development
visual behavior
response to xenobiotic stimulus
response to light stimulus
response to wounding
neutral amino acid transport
L-glutamate transport
telencephalon development
adult behavior
multicellular organism growth
response to amino acid
positive regulation of glucose import
protein homotrimerization
L-aspartate transmembrane transport
D-aspartate import
cellular response to cocaine
cellular response to hypoxia
anion transmembrane transport
L-glutamate import across plasma membrane
neurotransmitter reuptake
L-aspartate import across plasma membrane
cysteine transmembrane transport
neurotransmitter transport
response to ethanol
response to antibiotic
amino acid transport
chemical synaptic transmission
transepithelial transport
glutamate homeostasis
import into cell
transport across blood-brain barrier
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support