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Invitrogen
EAAT4 Polyclonal Antibody
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产品信息
PA5-117412
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of mouse EAAT4. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.28 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Centrifuge briefly prior to opening.
靶标信息
Slc1a6 encodes a protein that is a glutamate transporters, also known as excitatory amino acid transporters (EAATs), are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain. There are five EAAT subtypes, each with a specific distribution. Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Slc1a6 functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Slc1a6 also mediates Cl(-) flux that is not coupled to amino acid transport and this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Further, Slc1a6 [lays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Excitatory amino acid transporter 4; high affinity aspartate/glutamate transporter; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6; solute carrier family 1, member 6
基因别名: EAAT4; Slc1a6
UniProt ID: (Rat) O35921, (Mouse) O35544
Entrez Gene ID: (Rat) 84012, (Mouse) 20513
