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Invitrogen
EB1 Monoclonal Antibody (KT51)
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EB1 Antibody (MA1-72531) in ICC/IF
Oncotarget 2021 -
Figure 9 Super-resolved images for EB1-mediated microtubule stabilization. The SIM images reveal clear localization of EB1 at the ends of microtubules in the control and EGCG treated cells. The EB1 localization was severely hampered and less abundant in MG treated cells. This effect of MG is inhibited in presence of EGCG. The rescued colocalization is visualized as yellow fluorescence.
产品信息
MA1-72531
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
KT51
抗原
The C-terminal part of mouse EB1 (amino acids 125-268)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody will not cross-react with mouse EB2 or human EB3.
靶标信息
EB1 family proteins are evolutionarily conserved proteins that bind microtubule plus-ends and centrosomes and regulate the dynamics and organization of microtubules. The MAPRE genes encode the EB1 family proteins. The human MAPRE genes MAPRE1, MAPRE2, and MAPRE3 code for EB1, RP1, and EBF3 proteins, respectively. EB1 family members appear to be expressed ubiquitously. The EB1 (MAPRE1) gene, at 20q11. 2, is fused to MLL in an adult patient with pro-B acute lymphoblastic leukemia. EB1 is a microtubule-associated protein that interacts with the colorectal adenomatous polyposis coli tumor-suppressor protein and plays important roles in regulating microtubule dynamics, cell polarity, and chromosome stability.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: adenomatous polyposis coli-binding protein EB1; APC-binding protein EB1; EB1; End-binding protein 1; MGC117374; MGC129946; Microtubule-associated protein RP/EB family member 1; microtubule-associated protein, RP/EB family, member 1
基因别名: EB1; MAPRE1
UniProt ID: (Human) Q15691
Entrez Gene ID: (Human) 22919
G2/M transition of mitotic cell cycle
sister chromatid cohesion
mitotic nuclear division
cell proliferation
positive regulation of cell migration
negative regulation of microtubule polymerization
protein localization to microtubule
cell division
cell-cell adhesion
positive regulation of microtubule plus-end binding
negative regulation of microtubule binding
