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Agrisera
ECA1/Calcium-transporting ATPase 1, endoplasmic reticulum-type Polyclonal Antibody
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产品信息
AS17-4156
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide derived from Arabidopsis thaliana ECA1 sequence, cytosolic loop, between TM4 and TM5.
偶联物
形式
Lyophilized
保存液
whole serum
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Lyophilized antibody can be stored at -20°C for up to 3 years. Re-constituted antibody can be stored at 4°C for several days to weeks. Once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
ECA1 encodes an endoplasmic reticulum (ER)-localized P-type ATPase (P2A class) that functions as an ER Ca2+/Mn2+ pump important for ion homeostasis and plant stress adaptation. The protein is a large, multi-pass integral membrane transporter with multiple transmembrane helices forming the cation translocation pathway and a cytosolic catalytic core containing the conserved P-type ATPase actuator (A), phosphorylation (P; Asp-containing), and nucleotide-binding (N) domains that drive ATP-dependent transport via a transient phosphoenzyme intermediate. Functional analyses show that ECA1 contributes substantially to ER-type Ca2+-pump activity in vivo and supports normal growth under low external Ca2+ and high Mn2+ conditions; loss of ECA1 causes conditional growth defects and impaired root hair elongation under Mn2+ stress. Biochemical assays in heterologous systems indicate multi-cation specificity, with Ca2+, Mn2+, and Zn2+ able to stimulate formation of the catalytic phosphointermediate, consistent with sequestration of these ions into the ER lumen to shape cytosolic ion dynamics and protect against metal toxicity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACA3; ARABIDOPSIS THALIANA ER-TYPE CA2+-ATPASE 1; AT1G07810; ATECA1; ER-TYPE CA2+-ATPASE; ER-type Ca2+-ATPase 1; F24B9.9; F24B9_9
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