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Invitrogen
ECD Polyclonal Antibody
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产品信息
PA5-52298
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: DEDFECLDSD DDLDFETHEP GEEASLKGTL DNLKSYMAQM DQELAHTCIS KSFTTRNQVE PVSQTTDNNS DEEDSGTGES VMAPVDVDLN LVSNILESYS SQAGLAGPAS NLLQSMGVQL PDNTDHRPTS KP
Highest antigen sequence identity to the following orthologs: Mouse - 64%, Rat - 69%.
靶标信息
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ecdysoneless homolog; hSGT1; Human suppressor of GCR two; Protein ecdysoneless homolog; protein SGT1; SGT1 protein; suppressor of GCR2; suppressor of S. cerevisiae gcr2
基因别名: ECD; GCR2; HSGT1; SGT1
UniProt ID: (Human) O95905
Entrez Gene ID: (Human) 11319
