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Invitrogen
ECE1 Polyclonal Antibody
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产品信息
PA5-110784
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: NEKVLTGYLN YMVQLGKLLG GGDEEAIRPQ MQQILDFETA LANITIPQEK RRDEELIYHK VTAAELQTLA PAINWLPFLN TIFYPVEINE SEPIVVYDKE YLEQISTLIN TTDRCLLNNY MIWNLVRKTS SFLDQRFQDA DEKFMEV
Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 96%.
靶标信息
Endothelin-converting enzyme 1 (ECE1) is located on chromosome 1p36.12 and encodes a zinc metalloprotease involved in the maturation of endothelin peptides, which are critical for vascular tone regulation and blood pressure control. ECE1 processes precursor proteins into active endothelins, particularly endothelin-1, the most potent vasoconstrictor known. This enzyme is expressed in multiple tissues, including endothelial cells, smooth muscle cells, and the central nervous system, where it participates in diverse physiological processes such as vasoconstriction, cell proliferation, and hormone secretion. Beyond its cardiovascular functions, ECE1 is implicated in neural development and neural crest cell migration. Dysregulation of ECE1 activity or endothelin signaling is associated with several pathologies, including hypertension, heart failure, and cancer progression due to its role in controlling vascular dynamics. Research into ECE1 aims to explore its therapeutic potential in managing cardiovascular disorders and its broader implications in systemic pathophysiology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ECE 1; ECE-1; Endothelin-converting enzyme 1
基因别名: ECE; ECE1
UniProt ID: (Human) P42892
Entrez Gene ID: (Human) 1889
response to hypoxia
positive regulation of receptor recycling
regulation of systemic arterial blood pressure by endothelin
apoptotic process
heart development
positive regulation of cardiac muscle hypertrophy
substance P catabolic process
bradykinin catabolic process
calcitonin catabolic process
protein processing
peptide hormone processing
regulation of vasoconstriction
positive regulation of cAMP biosynthetic process
endothelin maturation
response to muscle stretch
regulation of vasodilation
hormone catabolic process
response to drug
embryonic digit morphogenesis
ear development
positive regulation of G-protein coupled receptor protein signaling pathway
response to cadmium ion
pharyngeal system development
regulation of ERK1 and ERK2 cascade
