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Invitrogen
EDB-FN Chimeric Recombinant Rabbit Monoclonal Antibody (A2)
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EDB-FN Chimeric Antibody (MA5-48023) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of EDB-FN in HeLa cells using EDB-FN Chimeric Monoclonal Antibody (Product # MA5-48023). Paraformaldehyde-fixed cells were stained with EDB-FN Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor488 secondary antibody (1 µg/mL), showing endoplasmic reticular staining. The nuclear stain is DAPI (blue). Panels show from left-right, top-bottom ... View More
产品信息
MA5-48023
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
A2
抗原
2D-PAGE gel isolated human Extra-Domain containing fibronectin from lysate of human melanoma COLO-38 cells.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: This antibody bind to human Extra-Domain containing fibronectin.
靶标信息
EDB-FN is a variant of the fibronectin protein that contains an extra domain, known as the extra domain B. This extra domain is not present in the normal fibronectin protein and has been found to be expressed in certain tissues during embryonic development and in tumors. The extra domain has been implicated in cell adhesion, migration, and invasion, and has been shown to play a role in the progression and metastasis of certain cancers. Due to its unique expression pattern and functional properties, EDB-FN has been investigated as a potential target for cancer therapy and imaging.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CIG; Cold-insoluble globulin; extra domain B; extra domain B of fibronectin; Fibronectin; FN; migration-stimulating factor
基因别名: CIG; ED-B; FINC; FN; FN1; FNZ; GFND; GFND2; LETS; MSF
UniProt ID: (Human) P02751
Entrez Gene ID: (Human) 2335
angiogenesis
cell activation
regulation of protein phosphorylation
platelet degranulation
response to ischemia
acute-phase response
cell-substrate junction assembly
cell adhesion
calcium-independent cell-matrix adhesion
positive regulation of cell proliferation
glial cell migration
regulation of cell shape
response to wounding
response to ozone
positive regulation of gene expression
positive regulation of peptidase activity
peptide cross-linking
extracellular matrix disassembly
extracellular matrix organization
integrin activation
substrate adhesion-dependent cell spreading
cellular response to vascular endothelial growth factor stimulus
endodermal cell differentiation
cellular response to platelet-derived growth factor stimulus
wound healing
negative regulation of apoptotic process
positive regulation of axon extension
positive regulation of fibroblast proliferation
leukocyte migration
positive regulation of chemotaxis
response to glucocorticoid
regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to mercury ion
cellular response to glucose stimulus
cellular response to interleukin-1
cellular response to prostaglandin E stimulus
cellular response to transforming growth factor beta stimulus
cellular response to BMP stimulus
positive regulation of substrate-dependent cell migration, cell attachment to substrate
negative regulation of transforming growth factor-beta secretion
