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Immunogen sequence: SLEKYTKVKC GYATLHHVID KSTEDRMESF FLSETCKYLY LLFDEDNPVH KSGTRYMFTT EGHIVSVDEH LRELPWKEFF SEEGGQDQGG KSVHRPKPHE LKVINSSSNC NRVPDE
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
EDEM1 belongs to the glycosyl hydrolase 47 family. It extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。