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产品信息
PA5-120535
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 399-578 of human EDEM2 (NP_060687.2).
偶联物
形式
Liquid
浓度
1.96 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914107
产品详细信息
Positive test controls include: A375, HepG2.
Immunogen sequence: SIEKISKVEC GFATIKDLRD HKLDNRMESF FLAETVKYLY LLFDPTNFIH NNGSTFDAVI TPYGECILGA GGYIFNTEAH PIDPAALHCC QRLKEEQWEV EDLMREFYSL KRSRSKFQKN TVSSGPWEPP ARPGTLFSPE NHDQARERKP AKQKVPLLSC PSQPFTSKLA LLGQVFLDSS
靶标信息
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ER degradation enhancer, mannosidase alpha-like 2; ER degradation-enhancing alpha-mannosidase-like 2; ER degradation-enhancing alpha-mannosidase-like protein 2; ER degradation-enhancing-mannosidase-like protein 2
基因别名: 9530090G24Rik; AI327354; bA4204.1; C20orf31; C20orf49; EDEM2; UNQ573/PRO1135
UniProt ID: (Human) Q9BV94, (Mouse) Q8BJT9
Entrez Gene ID: (Human) 55741, (Mouse) 108687
glycoprotein binding
alpha-mannosidase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
calcium ion binding
molecular_function
lytic transglycosylase activity
mannosidase activity
mannosyl-oligosaccharide mannosidase activity
galactosidase activity
glucosidase activity
trehalase activity
fucosidase activity
hexosaminidase activity
amylase activity
dextrin alpha-glucosidase activity
starch alpha-glucosidase activity
beta-glucanase activity
beta-6-sulfate-N-acetylglucosaminidase activity
glucan endo-1,4-beta-glucosidase activity
N-glycan processing
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
trimming of terminal mannose on B branch
glycoprotein ERAD pathway
positive regulation of retrograde protein transport, ER to cytosol
endoplasmic reticulum mannose trimming
mannose trimming involved in glycoprotein ERAD pathway
biological_process
