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Invitrogen
EDEM3 Polyclonal Antibody
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图: 1 / 5
EDEM3 Antibody (PA5-115159) in IHC (P)
Immunohistochemistry analysis of EDEM3 in human gastric cancer. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115159) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-115159
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human EDEM3(Accession Q9BZQ6), corresponding to amino acid residues S769-Q819.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total EDEM3.
靶标信息
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha-1,2-mannosidase EDEM3; ER degradation enhancer, mannosidase alpha-like 3; ER degradation-enhancing -mannosidase-like protein 3; ER degradation-enhancing alpha-mannosidase-like 3; unnamed protein product
基因别名: 2310050N11Rik; C1orf22; CDG2V
UniProt ID: (Human) Q9BZQ6, (Mouse) Q2HXL6
Entrez Gene ID: (Human) 80267, (Mouse) 66967
carbohydrate metabolic process
glycoprotein catabolic process
endoplasmic reticulum unfolded protein response
ERAD pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
glycoprotein ERAD pathway
endoplasmic reticulum mannose trimming
mannose trimming involved in glycoprotein ERAD pathway
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