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Invitrogen
EDG3 Recombinant Rabbit Monoclonal Antibody (13C19)
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EDG3 Antibody (MA573441) in WB
Western blot analysis of EDG3 in PC-12 and PC-3 lysates (25 µg/lane). Samples were incubated with EDG3 Recombinant Monoclonal (Product # MA573441) at 1:1,000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at room temperature for 60 min.
产品信息
MA573441
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
13C19
抗原
KLH conjugated synthetic peptide derived from human EDG3.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
20 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
EDG-3 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-3 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-3 is expressed in cardiovascular, leukocyte-containing and other tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cardiac sphingosine-1-phosphate specific receptor; edg3; G protein-coupled; Endothelial differentiation G-protein coupled receptor 3; endothelial differentiation sphingolipid G-protein-coupled receptor 3; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3; FLJ37523; FLJ93220; G protein-coupled receptor, endothelial differentiation gene-3; Lysophospholipid receptor B3; MGC71696; S1P receptor 3; S1P receptor Edg-3; S1P receptor EDG3; S1P receptor S1P3; sphingosine; Sphingosine 1-phosphate receptor 3; Sphingosine 1-phosphate receptor Edg-3; uncharacterized protein C9orf47; unnamed protein product
基因别名: AI132464; bA791O21.3; C9orf108; C9orf47; EDG-3; EDG3; Edg3l; LPB3; S1P3; S1PR3
UniProt ID: (Human) Q99500, (Mouse) Q9Z0U9
Entrez Gene ID: (Human) 1903, (Mouse) 13610, (Rat) 306792
sphingosine-1-phosphate signaling pathway
inflammatory response
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
Notch signaling pathway
positive regulation of cell proliferation
anatomical structure morphogenesis
regulation of interleukin-1 beta production
negative regulation of establishment of endothelial barrier
cytokine production
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