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Invitrogen
EEF2K Polyclonal Antibody
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产品信息
PA5-120913
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 406-725 of human EEF2K (NP_037434.1).
偶联物
形式
Liquid
浓度
0.86 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: HepG2, HeLa, LOVO, 22Rv1, 293T, Mouse spleen.
Immunogen sequence: KLDHLHWPVF SDLDNMASRD HDHLDNHRES ENSGDSGYPS EKRGELDDPE PREHGHSYSN RKYESDEDSL GSSGRVCVEK WNLLNSSRLH LPRASAVALE VQRLNALDLE KKIGKSILGK VHLAMVRYHE GGRFCEKGEE WDQESAVFHL EHAANLGELE AIVGLGLMYS QLPHHILADV SLKETEENKT KGFDYLLKAA EAGDRQSMIL VARAFDSGQN LSPDRCQDWL EALHWYNTAL EMTDCDEGGE YDGMQDEPRY MMLAREAEML FTGGYGLEKD PQRSGDLYTQ AAEAAMEAMK GRLANQYYQK AEEAWAQMEE
靶标信息
EEF2K is a highly conserved Serine/Threoning kinase in the calmodulin signaling pathway whose activity is increased in cancers including breast cancer. EEF2K (eukaryotic elongation factor 2 kinase) is a threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Up activation, by a variety of upstream kinases including AMPK or TRPM7, EEF2K phosphorylates the elongation factor EEF2 at a single site. Then, EEF2K renders EEF2 unable to bind ribosomes and inactive - in turn, the rate of protein synthesis is reduced.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; EC 2.7.11.20; eEF-2 kinase; EF2K; elongation factor-2 kinase; euk; eukaroytic elongation factor 2 kinase; Eukaryotic elongation factor 2 kinase; eukaryotic elongation factor-2 kinase; kinase eEF2K
基因别名: C86191; eEF-2K; EEF2K; HSU93850
UniProt ID: (Human) O00418, (Mouse) O08796
Entrez Gene ID: (Human) 29904, (Mouse) 13631
protein kinase activity
elongation factor-2 kinase activity
calcium ion binding
calmodulin binding
ATP binding
translation factor activity, RNA binding
nucleotide binding
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
response to ischemia
translational elongation
regulation of protein autophosphorylation
cellular response to insulin stimulus
negative regulation of apoptotic process
positive regulation of endocytosis
protein autophosphorylation
positive regulation of synapse assembly
positive regulation of dendritic spine morphogenesis
cellular response to calcium ion
cellular response to cAMP
cellular response to anoxia
cellular response to brain-derived neurotrophic factor stimulus
response to prolactin
protein phosphorylation
phosphorylation
