Search

  • 联系我们
  • 货号直购

Invitrogen

EGFR (Matuzumab Biosimilar) Recombinant Rabbit Monoclonal Antibody (Matuzumab)

查看其他254个EGFR抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
说明书
证书
实验方案
问题与答案
技术支持
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

产品信息

MA5-47998

应用
建议稀释比
已发表文章

免疫印迹 (WB)

Assay-dependent
-

免疫细胞化学 (ICC/IF)

10 µg/mL
-

流式细胞分析 (Flow)

10 µg/mL
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-

功能检测 (Functional)

Assay-dependent
-

抑制试剂 (Inhibition)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

Matuzumab

抗原

Domain III of the extracellular domain of human EGRF.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

200 µg

纯化类型

Protein A

保存液

PBS

内含物

0.02% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3074441

产品详细信息

Specificity: This antibody binds the extracellular domain III of the human EGFR and does not cross react with murine EGFR. It was also reported that residues S460/G461 in EGFR domain III are essential components of the epitope. This antibody binds at a site distinct from the EGF binding site, preventing conformational re-arrangement required for dimerization, a process essential for high-affinitiy ligand binding. This antibody can only recognize the active form of EGFR. The antibody binds to both glyco- and aglyco receptor forms.

MA5-47998 is a chimeric antibody. The variable regions from one species have been grafted to the backbone of the other species.

靶标信息

EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics. EGFR is encoded by the EGFR gene located on chromosome 7 in humans. EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain. Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: 2.7.10.1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; contains extracellular domain; EC 2.7.10.1; EGFR vIII; Epidermal growth factor receptor; epidermal growth factor receptor tyrosine kinase domain; erb-b2 receptor tyrosine kinase 1; GIG40; kinase EGFR; membrane protein; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; unnamed protein product; Urogastrone

查看更多 收起

基因别名: EGFR; ERBB; ERBB1; ERRP; HER1; mENA; NISBD2; NNCIS; PIG61

查看更多 收起

UniProt ID: (Human) P00533

查看更多 收起

Entrez Gene ID: (Human) 1956

查看更多 收起

功能
nucleotide binding virus receptor activity chromatin binding double-stranded DNA binding protein kinase activity MAP kinase kinase kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity epidermal growth factor-activated receptor activity protein binding ATP binding kinase activity transferase activity enzyme binding kinase binding protein phosphatase binding protein tyrosine kinase activator activity ubiquitin protein ligase binding identical protein binding cadherin binding epidermal growth factor binding actin filament binding ATPase binding
参与通路
MAPK cascade cell morphogenesis ossification embryonic placenta development positive regulation of protein phosphorylation hair follicle development signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway salivary gland morphogenesis learning or memory cell proliferation positive regulation of cell proliferation epidermis development cerebral cortex cell migration neuron differentiation positive regulation of cell growth positive regulation of cell migration positive regulation of peptidyl-serine phosphorylation ERBB2-EGFR signaling pathway negative regulation of epidermal growth factor receptor signaling pathway regulation of cell proliferation negative regulation of protein catabolic process positive regulation of phosphorylation negative regulation of apoptotic process positive regulation of MAPK cascade protein kinase B signaling positive regulation of DNA repair positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter viral entry into host cell positive regulation of fibroblast proliferation digestive tract morphogenesis epithelial cell proliferation positive regulation of epithelial cell proliferation regulation of peptidyl-tyrosine phosphorylation protein insertion into membrane positive regulation of protein kinase B signaling morphogenesis of an epithelial fold eyelid development in camera-type eye response to UV-A positive regulation of ERK1 and ERK2 cascade cellular response to amino acid stimulus cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus cellular response to estradiol stimulus positive regulation of protein kinase C signaling positive regulation of canonical Wnt signaling pathway cell-cell adhesion positive regulation of G1/S transition of mitotic cell cycle positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of protein localization to plasma membrane negative regulation of cardiocyte differentiation
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持