Invitrogen

EGR2 Polyclonal Antibody

查看其他23个EGR2抗体

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EGR2 Polyclonal Antibody

产品信息

PA5-90195

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human EGR2 (NP_0003902)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.92 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2805956

产品详细信息

Immunogen sequence: LAYPPPPSYP SPKPATDPGL FPMIPDYPGF FPSQCQRDLH GTAGPDRKPF PCPLDTLRVP PPLTPLSTIR NFTLGGPSAG VTGPGASGGS EGPRLPGSSS A; Positive Samples: mouse kidney; Cellular Location: Nucleus

靶标信息

The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are referred to as transcription factors. The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the fatty substance that covers and protects nerve cells. Myelin promotes the efficient transmission of nerve impulses. If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired. Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DKFZp686J1957; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; Early growth response protein 2; EGR-2; FLJ1454; FLJ14547; Krox-20 homolog; OTTHUMP00000062133; Zinc finger protein Krox-20

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基因别名: Egr-2; Egr2; Krox-20; Krox20; NGF1-B; Zfp-25; Zfp-6

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UniProt ID: (Mouse) P08152

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Entrez Gene ID: (Mouse) 13654

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ligase activity ribosomal S6-glutamic acid ligase activity ubiquitin protein ligase binding coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity transcription regulatory region DNA binding metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity HMG box domain binding C2H2 zinc finger transcription factor
参与通路
transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter protein export from nucleus rhythmic behavior motor neuron axon guidance Schwann cell differentiation rhombomere 3 development facial nerve structural organization rhombomere 3 formation rhombomere 5 formation regulation of ossification response to insulin brain segmentation skeletal muscle cell differentiation myelination negative regulation of apoptotic process fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of neuronal synaptic plasticity cellular response to organic substance cellular response to cAMP cellular response to gonadotropin stimulus
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