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Invitrogen

EGR2 Recombinant Rabbit Monoclonal Antibody (K01_3Y21)

查看其他24个EGR2抗体

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产品信息

MA567150

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_3Y21

抗原

A synthesized peptide derived from human EGR2.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 50% glycerol, 0.05% BSA, 150mM NaCl

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The EGR2 gene provides instructions for making a protein called early growth response 2, which is part of the early growth response family of proteins. These proteins bind to specific areas of DNA and help control the activity of particular genes. On the basis of this action, the proteins are referred to as transcription factors. The early growth response 2 protein activates several genes that are involved in the formation and maintenance of myelin, the fatty substance that covers and protects nerve cells. Myelin promotes the efficient transmission of nerve impulses. If myelin is lost (demyelination) or its structure is disrupted, the transmission of nerve impulses is impaired. Mutations in the EGR2 gene can cause two forms of Charcot-Marie-Tooth disease, type 1D or type 4E (sometimes called congenital hypomyelinating neuropathy) or a severe form of type 1D (sometimes called Dejerine-Sottas syndrome) that begins during infancy or early childhood.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: AT591; DKFZp686J1957; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; early growth response 2 protein; Early growth response protein 2; EGR-2; FLJ1454; FLJ14547; Krox-20 homolog; KROX-20, Drosophila, homolog (early growth response-2); OTTHUMP00000062133; unnamed protein product; Zinc finger protein Krox-20

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基因别名: AT591; CMT1D; CMT4E; Egr-2; EGR2; Krox-20; KROX20; NGF1-B; Zfp-25; Zfp-6

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UniProt ID: (Human) P11161, (Mouse) P08152, (Rat) P51774

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Entrez Gene ID: (Human) 1959, (Mouse) 13654, (Rat) 114090

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功能
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding transferase activity ubiquitin protein ligase binding sequence-specific DNA binding metal ion binding RNA polymerase II sequence-specific DNA binding transcription factor binding SUMO ligase activity sequence-specific double-stranded DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding nucleic acid binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity transcription regulatory region DNA binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity HMG box domain binding C2H2 zinc finger transcription factor
参与通路
regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein export from nucleus brain development peripheral nervous system development rhythmic behavior motor neuron axon guidance gene expression Schwann cell differentiation positive regulation of Schwann cell differentiation protein sumoylation rhombomere 3 development facial nerve structural organization rhombomere 3 structural organization rhombomere 3 formation rhombomere 5 structural organization rhombomere 5 formation regulation of ossification positive regulation of myelination brain segmentation aorta development skeletal muscle cell differentiation myelination fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter transcription, DNA-templated transcription from RNA polymerase II promoter response to insulin negative regulation of apoptotic process regulation of neuronal synaptic plasticity cellular response to organic substance cellular response to cAMP cellular response to gonadotropin stimulus learning or memory
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