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Invitrogen
EHHADH Polyclonal Antibody
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Product Details
PA5-37009
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 518-563 of human EHHADH
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 79 kDa.
Purity is >95% by SDS-PAGE.
Target Information
As an L-hydroxy-specific enzyme, EHHADH (enoyl-CoA-hydratase:3-hydroxyacyl-CoA dehydrogenase), also known as Peroxisomal L-bifunctional enzyme, is a 723 amino acid protein has an essential tripeptide sequence on its carboxyl-terminus that is required for peroxisomal transport. EHHADH-null mice only exhibit a blunted peroxisome proliferative response when challenged with a peroxisome proliferator. Since there were no observed changes in lipid metabolism, this evidence suggests that enoyl-CoAs were diverted to the D-hydroxy-specific beta-oxidation system for metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3,2-trans-enoyl-CoA isomerase; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; L-3-hydroxyacyl-CoA dehydrogenase; L-bifunctional enzyme; L-bifunctional protein; L-bifunctional protein, peroxisomal; L-PBE; L-peroxisomal bifunctional enzyme; L-specific bifunctional protein; L-specific multifunctional beta-oxdiation protein; LBP; MFE1; MFP-1; MFP1; Multifunctional enzyme 1; multifunctional enzyme type 1; Multifunctional protein 1; PBE; Peroxisomal bifunctional enzyme; peroxisomal bifunctional enzyme type 1; peroxisomal enoyl-CoA hydratase; unnamed protein product
Gene Aliases: ECHD; EHHADH; HD; LBFP; LBP; MEF; Mfe; MFP; Pbe; PBFE; 1; 1300002P22Rik; FRTS3; L-PBE; MFE1; MFP1; perMFE-1
UniProt ID: (Human) Q08426, (Mouse) Q9DBM2, (Rat) P07896
Entrez Gene ID: (Human) 1962, (Mouse) 74147, (Rat) 171142
catalytic activity
3-hydroxyacyl-CoA dehydrogenase activity
dodecenoyl-CoA delta-isomerase activity
enoyl-CoA hydratase activity
protein binding
oxidoreductase activity
long-chain-3-hydroxyacyl-CoA dehydrogenase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
lyase activity
isomerase activity
intramolecular oxidoreductase activity, transposing C=C bonds
3-hydroxyacyl-CoA dehydratase activity
enzyme binding
NAD+ binding
receptor binding
coenzyme binding
dehydrogenase
lipid metabolic process
fatty acid metabolic process
fatty acid beta-oxidation
unsaturated fatty acid biosynthetic process
fatty acid beta-oxidation using acyl-CoA oxidase
alpha-linolenic acid metabolic process
long-chain fatty acid biosynthetic process
fatty acid derivative biosynthetic process
internal protein amino acid acetylation
acyl-CoA metabolic process
metabolic process
oxidation-reduction process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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