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Invitrogen
ELP3 Recombinant Rabbit Monoclonal Antibody (3R3U5)
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ELP3 Antibody (MA5-42582) in IHC (P)
Immunohistochemistry analysis of ELP3 in paraffin-embedded rat brain using. Samples were incubated with ELP3 Monoclonal antibody (Product # MA5-42582) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-42582
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3R3U5
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-547 of human KAT9/Elp3 (Q9H9T3).
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: MCF7, K-562, SH-SY5Y, Mouse testis, Mouse brain, Mouse kidney, Rat lung, Rat testis, Rat brain. The target is usually found in the following locations: Cytoplasm, Nucleus.
Immunogen sequence: MRQKRKGDLS PAELMMLTIG DVIKQLIEAH EQGKDIDLNK VKTKTAAKYG LSAQPRLVDI IAAVPPQYRK VLMPKLKAKP IRTASGIAVV AVMCKPHRCP HISFTGNICV YCPGGPDSDF EYSTQSYTGY EPTSMRAIRA RYDPFLQTRH RIEQLKQLGH SVDKVEFIVM GGTFMALPEE YRDYFIRNLH DALSGHTSNN IYEAVKYSER SLTKCIGITI ETRPDYCMKR HLSDMLTYGC TRLEIGVQSV YEDVARDTNR GHTVKAVCES FHLAKDSGFK VVAHMMPDLP NVGLERDIEQ FTEFFENPAF RPDGLKLYPT LVIRGTGLYE LWKSGRYKSY SPSDLVELVA RILALVPPWT RVYRVQRDIP MPLVSSGVEH GNLRELALAR MKDLGIQCRD VRTREVGIQE IHHKVRPYQV ELVRRDYVAN GGWETFLSYE DPDQDILIGL LRLRKCSEET FRFELGGGVS IVRELHVYGS VVPVSSRDPT KFQHQGFGML LMEEAERIAR EEHGSGKIAV ISGVGTRNYY RKIGYRLQGP YMVKMLK
靶标信息
Elongator complex protein 3 (ELP3) is a catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. It may also have a methyltransferase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EC 2.3.1.48; elongation protein 3 homolog; Elongator complex protein 3; h KAT9; hELP3; rCG52086-like; tRNA uridine(34) acetyltransferase
基因别名: 2610507P14Rik; ELP3; KAT9
UniProt ID: (Human) Q9H9T3, (Mouse) Q9CZX0
Entrez Gene ID: (Human) 55140, (Mouse) 74195, (Rat) 100362548
RNA polymerase II core binding
protein binding
phosphorylase kinase regulator activity
H3 histone acetyltransferase activity
H4 histone acetyltransferase activity
metal ion binding
iron-sulfur cluster binding
catalytic activity
histone acetyltransferase activity
N-acetyltransferase activity
transferase activity
transferase activity, transferring acyl groups
DNA binding
histone modifying enzyme
neuron migration
tRNA wobble uridine modification
regulation of transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
central nervous system development
positive regulation of cell migration
histone H3 acetylation
histone H4 acetylation
regulation of protein kinase activity
transcription, DNA-templated
regulation of transcription, DNA-templated
nervous system development
histone acetylation
