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Abnova
ENG Monoclonal Antibody (4C11)
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产品信息
H00002022-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
4C11
抗原
ENG (AAH14271, 27 a.a. approximately 658 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: TVHCDLQPVG PERDEVTYTT SQVSKGCVAQ APNAILEVHV LFLEFPTGPS QLELTLQASK QNGTWPREVL LVLSVNSSVF LHLQALGIPL HLAYNSSLVT FQEPPGVNTT ELPSFPKTQI LEWAAERGPI TSAAELNDPQ SILLRLGQAQ GSLSFCMLEA SQDMGRTLEW RPRTPALVRG CHLEGVAGHK EAHILRVLPG HSAGPRTVTV KVELSCAPGD LDAVLILQGP PYVSWLIDAN HNMQIWTTGE YSFKIFPEKN IRGFKLPDTP QGLLGEARML NASIVASFVE LPLASIVSLH ASSCGGRLQT SPAPIQTTPP KDTCSPELLM SLIQTKCADD AMTLVLKKEL VAHLKCTITG LTFWDPSCEA EDRGDKFVLR SAYSSCGMQV SASMISNEAV VNILSSSSPQ RKKVHCLNMD SLSFQLGLYL SPHFLQASNT IEPGQQSFVQ VRVSPSVSEF LLQLDSCHLD LGPEGGTVEL IQGRAAKGNC VSLLSPSPEG DPRFSFLLHF YTVPIPKTGT LSCTVALRPK TGSQDQEVHR TVFMRLNIIS PDLSGCTSKG LVLPAVLGIT FGAFLIGALL TAALWYIYSH TRSPSKREPV VAVAAPASSE SSSTNHSIGS TQSTPCSTSS MA
靶标信息
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD105; CD105 antigen; Endoglin; ORW
基因别名: END; ENG; HHT1; ORW1
UniProt ID: (Human) P17813
Entrez Gene ID: (Human) 2022
transmembrane signaling receptor activity
transforming growth factor beta receptor, cytoplasmic mediator activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
type I transforming growth factor beta receptor binding
BMP binding
protein homodimerization activity
activin binding
transforming growth factor beta binding
transmembrane signal receptor
chronological cell aging
patterning of blood vessels
vasculogenesis
positive regulation of protein phosphorylation
heart looping
sprouting angiogenesis
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
cell migration involved in endocardial cushion formation
regulation of transcription, DNA-templated
cell adhesion
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
negative regulation of cell migration
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of protein autophosphorylation
dorsal aorta morphogenesis
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
endocardial cushion to mesenchymal transition
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
