NeoBiotechnologies

ER-beta (Estrogen Receptor beta-1) Monoclonal Antibody (PGP5/10)

查看其他34个Estrogen Receptor beta抗体

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说明书
实验方案
问题与答案
技术支持
ER-beta (Estrogen Receptor beta-1) Monoclonal Antibody (PGP5/10)

产品信息

2100-MSM10-P0

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1-2 µg/mL
-

免疫组化（石蜡） (IHC (P))

Assay-dependent
-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1-2 µg/mL
-

免疫细胞化学 (ICC/IF)

2-4 µg/mL
-

流式细胞分析 (Flow)

2-4 µg/10^6 cells
-
产品规格

种属反应

Horse, Human, Mouse, Non-human primate, Sheep, Pig, Rat

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

PGP5/10

抗原

A Synthetic peptide (CEDSKSKEGSQNPQSQ) from the C terminus of the human estrogen receptor beta 1 isomer
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4°C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ER; ER beta; ER-beta; estradiol receptor beta; estrogen receptor 2 (ER beta); estrogen receptor 2 beta; Estrogen receptor beta; estrogen receptor beta 4; Nuclear receptor subfamily 3 group A member 2; oestrogen receptor beta; steroid receptor

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基因别名: er; ER-BETA; ER2; ER[b]; ERB; Erb2; ERBETA; ESR-BETA; ESR2; ESRB; ESTRB; NR3A2

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UniProt ID: (Pig) Q9XSW2, (Human) O75584, (Sheep) Q9TU15, (Mouse) O08537, (Rat) Q62986

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Entrez Gene ID: (Pig) 396697, (Human) 2100, (Horse) 100033964, (Sheep) 443066, (Mouse) 13983, (Rat) 25149

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功能
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding steroid binding zinc ion binding estrogen receptor activity sequence-specific DNA binding core promoter sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity protein binding drug binding enzyme binding estrogen response element binding RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding peroxisome proliferator activated receptor binding receptor antagonist activity estradiol binding steroid hormone binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding lipid binding hormone binding metal ion binding
参与通路
negative regulation of transcription from RNA polymerase II promoter ovarian follicle development behavioral fear response neuron migration transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter brain development learning or memory negative regulation of cell proliferation hormone-mediated apoptotic signaling pathway intracellular steroid hormone receptor signaling pathway intracellular estrogen receptor signaling pathway response to testosterone regulation of cell proliferation positive regulation of apoptotic process steroid hormone mediated signaling pathway regulation of neuron apoptotic process estrous cycle positive regulation of epidermal growth factor receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of behavior negative regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity Sertoli cell proliferation uterus development vagina development negative regulation of cell death prostate gland epithelium morphogenesis epithelial cell maturation involved in prostate gland development negative regulation of androgen receptor signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of neuron death negative regulation of feeding behavior negative regulation of reactive oxygen species metabolic process cellular response to estradiol stimulus transcription initiation from RNA polymerase II promoter signal transduction cell-cell signaling response to water deprivation response to activity response to insecticide cerebellum development amygdala development hypothalamus development negative regulation of cell growth prostate gland development response to nutrient levels response to genistein cellular response to drug response to estrogen response to human chorionic gonadotropin response to ethanol positive regulation of vasodilation Sertoli cell development cellular response to magnetism response to dexamethasone extracellular negative regulation of signal transduction response to salt response to bisphenol A male gonad development female gonad development response to hormone response to organic cyclic compound response to estradiol response to drug cellular response to organic cyclic compound
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