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Invitrogen
ERAB Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-9002
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the C terminus amino acids CIRLDGAIRMQP (aa 251-261).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
靶标信息
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; AB-binding alcohol dehydrogenase; amyloid-beta peptide binding alcohol dehydrogenase; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; HADH2; HADH2 protein; hydroxysteroid (17-beta) dehydrogenase 10 isoform HSD17B10_1; hydroxysteroid (17-beta) dehydrogenase 10 isoform HSD17B10_2; mitochondrial ribo; mitochondrial ribonuclease P protein 2; mitochondrial RNas; mitochondrial RNase P subunit 2; RP3-339A18.2; short chain L-3-hydroxyacyl-CoA dehydrogenase type 2; short chain type dehydrogenase/reductase XH98G2; type 10 17b-HSD; X-linked alcohol dehydrogenase
基因别名: 17b-HSD10; ABAD; CAMR; DUPXp11.22; ERAB; HADH2; HCD2; HSD10MD; MHBD; MRPP2; MRX17; MRX31; MRXS10; SCHAD; SDR5C1
UniProt ID: (Human) Q99714
Entrez Gene ID: (Human) 3028
tRNA binding
RNA binding
3-hydroxyacyl-CoA dehydrogenase activity
estradiol 17-beta-dehydrogenase activity
protein binding
cholate 7-alpha-dehydrogenase activity
long-chain-3-hydroxyacyl-CoA dehydrogenase activity
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
testosterone dehydrogenase (NAD+) activity
androstan-3-alpha,17-beta-diol dehydrogenase activity
chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
cardiolipin dehydrogenase (NAD+) activity
tRNA 3'-terminal CCA addition
isoleucine catabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid beta-oxidation
bile acid biosynthetic process
mitochondrion organization
C21-steroid hormone metabolic process
androgen metabolic process
estrogen metabolic process
tRNA 3'-end processing
protein homotetramerization
brexanolone metabolic process
mitochondrial tRNA methylation
mitochondrial tRNA 5'-end processing
mitochondrial tRNA 3'-end processing
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