Proteintech

ERCC3 Polyclonal Antibody

2 篇参考文献
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说明书
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ERCC3 Polyclonal Antibody

产品信息

10580-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
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免疫沉淀 (IP)

0.5-4.0 µg
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

ERCC3 Fusion Protein Ag0876 (482-782 aa encoded by BC008820)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.26 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: FLIGPKLYE ANWMELQNNG YIAKVQCAEV WCPMSPEFYR EYVAIKTKKR ILLYTMNPNK FRACQFLIKF HERRNDKIIV FADNVFALKE YAIRLNKPYI YGPTSQGERM QILQNFKHNP KINTIFISKV GDTSFDLPEA NVLIQISSHG GSRRQEAQRL GRVLRAKKGM VAEEYNAFFY SLVSQDTQEM AYSTKRQRFL VDQGYSFKVI TKLAGMEEED LAFSTKEEQQ QLLQKVLAAT DLDAEEEVVA GEFGSRSSQA SRRFGTMSSM SGADDTVYME YHSSRSKAPS KHVHPLFKRF RK (482-782 aa encoded by BC008820)

靶标信息

The human XPB DNA helicase is a subunit of the DNA repair/basal transcription factor TFIIH, and is involved in early steps of the nucleotide excision repair (NER) pathway. Two distinct clinical phenotypes, xeroderma pigmentosum associated with Cockayne's syndrome (XP/CS) and trichothiodystrophy (TTD), can be due to mutations in the XPB gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Basic transcription factor 2 89 kDa subunit; BTF2 p89; BTF2-p89; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; DNA repair helicase; DNA repair protein complementing XP-B cells; excision repair 3; excision repair cross-complementation group 3; excision repair cross-complementing rodent repair deficiency, complementation group 3; General transcription and DNA repair factor IIH helicase/translocase subunit XPB; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH p89; TFIIH subunit XPB; Xeroderma pigmentosum group B-complementing protein; xeroderma pigmentosum, complementation group B

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基因别名: BTF2; BTF2 p89; Ercc-3; ERCC3; GTF2H; RAD25; TFIIH; TTD2; XPB; XPBC

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UniProt ID: (Human) P19447, (Mouse) P49135, (Rat) Q4G005

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Entrez Gene ID: (Human) 2071, (Mouse) 13872, (Rat) 291703

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功能
DNA binding damaged DNA binding ATP-dependent DNA helicase activity helicase activity protein kinase activity protein binding ATP binding GTP binding protein C-terminus binding DNA-dependent ATPase activity transcription factor binding RNA polymerase II carboxy-terminal domain kinase activity ATPase activity dATP binding peptide binding 3'-5' DNA helicase activity protein N-terminus binding nucleotide binding hydrolase activity DNA metabolism protein DNA helicase nucleic acid metabolism protein
参与通路
nucleotide-excision repair, DNA duplex unwinding response to hypoxia DNA topological change DNA repair transcription-coupled nucleotide-excision repair nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping protein phosphorylation apoptotic process response to oxidative stress protein localization response to UV UV protection viral process nucleotide-excision repair, DNA incision hair cell differentiation positive regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter embryonic organ development global genome nucleotide-excision repair regulation of mitotic cell cycle phase transition transcription, DNA-templated regulation of transcription, DNA-templated cellular response to DNA damage stimulus
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