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Invitrogen
ERCC8 Polyclonal Antibody
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产品信息
PA5-21281
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human ERCC8. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
5.39 mg/mL
纯化类型
Protein A
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: Molt-4, C8D30, Rat2.
Predicted reactivity: Mouse (91%), Rat (91%), Bovine (94%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cockayne syndrome 1 (classical); Cockayne syndrome 1 homolog; Cockayne syndrome WD repeat protein CSA; Cockayne syndrome WD repeat protein CSA homolog; Cockayne syndrome WD-repeat protein CSA; DNA excision repair protein ERCC-8; excision repair cross-complementation group 8; excision repair cross-complementing rodent repair deficiency complementation group 8; excision repair cross-complementing rodent repair deficiency, complementation group 8; excision repaiross-complementing rodent repair deficiency, complementation group 8
基因别名: 2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik; CKN1; CSA; ERCC8; UVSS2
UniProt ID: (Human) Q13216, (Mouse) Q8CFD5
Entrez Gene ID: (Human) 1161, (Rat) 310071, (Mouse) 71991
protein polyubiquitination
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
cellular response to DNA damage stimulus
response to oxidative stress
response to UV
response to X-ray
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
biological_process
positive regulation of DNA repair
DNA repair
