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ERK1 C-Term Polyclonal Antibody

查看其他45个ERK1抗体

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产品信息

600-401-GP9S

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1 µg/mL
-

酶联免疫吸附实验 (ELISA)

1:40,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Anti-ERK1 Antibody was produced in rabbits by repeated immunizations with synthetic peptide corresponding to amino acid residues near the C-terminus conjugated to KLH.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

25 µg

纯化类型

Affinity chromatography

保存液

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

内含物

0.01% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 µL). To minimize loss of volume dilute 1:10 by adding 225 µL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.

This affinity purified antibody is directed against human ERK1 protein. Cross reactivity is expected to occur with human, mouse and rat based on sequence identity of the peptide immunogen. This antibody does not react with the ERK2 isoform.

靶标信息

MAPK3 (ERK1) is a serine/threonine kinase that is an important activator of p90, RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway. ERK1 is widely expressed and involved in the regulation of meiosis, mitosis, and post-mitotic functions in differentiated cells. Many different stimuli, including growth factors, cytokines, virus infection, ligands for heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors and transforming agents, activate the ERK1 and ERK2 pathways. Functionally, ERK1 is involved with a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. ERK1 is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms of ERK1 have been described.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: ERK; ERK-1; Erk1; cancer susceptibility protein; ERK1b; ERK1c; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAP kinase2; MAPK 1; MAPK 3; MAPK2; Microtubule-associated protein 2 kinase; mitogen-activated 3; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MNK1; p44 MAP kinase; p44-ERK1; p44-MAPK; pp42/MAP kinase; unnamed protein product

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基因别名: ERK-1; ERK1; ERT2; Esrk1; HS44KDAP; HUMKER1A; MAPK1; MAPK3; MNK1; Mtap2k; p44; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM3

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UniProt ID: (Human) P27361, (Rat) P21708, (Mouse) Q63844

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Entrez Gene ID: (Human) 5595, (Rat) 50689, (Mouse) 26417

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功能
nucleotide binding phosphotyrosine binding protein kinase activity protein serine/threonine kinase activity MAP kinase activity protein binding ATP binding kinase activity transferase activity phosphatase binding identical protein binding protein serine kinase activity DNA-binding transcription factor binding scaffold protein binding transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
参与通路
autophagosome assembly MAPK cascade negative regulation of T cell mediated immune response to tumor cell transcription, DNA-templated protein phosphorylation apoptotic process cellular response to DNA damage stimulus cell surface receptor signaling pathway epidermal growth factor receptor signaling pathway insulin receptor signaling pathway organ morphogenesis regulation of gene expression negative regulation of autophagy positive regulation of autophagy positive regulation of macrophage chemotaxis neural crest cell development Schwann cell development phosphorylation sensory perception of pain regulation of ossification BMP signaling pathway regulation of cellular pH thyroid gland development positive regulation of cyclase activity lipopolysaccharide-mediated signaling pathway cellular response to nutrient levels positive regulation of telomere maintenance negative regulation of proteasomal ubiquitin-dependent protein catabolic process response to lipopolysaccharide regulation of stress-activated MAPK cascade cellular response to amino acid starvation intracellular signal transduction peptidyl-tyrosine autophosphorylation ERBB2-ERBB3 signaling pathway TORC1 signaling outer ear morphogenesis myelination glucose homeostasis signal transduction in response to DNA damage response to exogenous dsRNA positive regulation of transcription from RNA polymerase II promoter insulin-like growth factor receptor signaling pathway thymus development modulation of synaptic transmission protein stabilization negative regulation of T cell activation cartilage development stress-activated MAPK cascade regulation of cytoskeleton organization Bergmann glial cell differentiation face development lung morphogenesis trachea formation cardiac neural crest cell development involved in heart development interleukin-34-mediated signaling pathway ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade interleukin-1-mediated signaling pathway response to epidermal growth factor cellular response to mechanical stimulus cellular response to tumor necrosis factor caveolin-mediated endocytosis regulation of Golgi inheritance negative regulation of cholesterol efflux xenophagy positive regulation of macrophage proliferation positive regulation of neuroinflammatory response negative regulation of TORC1 signaling positive regulation of xenophagy regulation of early endosome to late endosome transport MAPK import into nucleus positive regulation of protein phosphorylation protein complex assembly DNA damage induced protein phosphorylation response to toxic substance peptidyl-serine phosphorylation arachidonic acid metabolic process positive regulation of histone phosphorylation positive regulation of histone acetylation positive regulation of translation positive regulation of transcription, DNA-templated regulation of sequence-specific DNA binding transcription factor activity negative regulation of apolipoprotein binding cell cycle signal transduction
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