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Invitrogen
ERLIN2 Recombinant Rabbit Monoclonal Antibody (JE57-03)
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ERLIN2 Antibody (MA5-44911) in IHC (P)
Immunohistochemistry analysis of Erlin-2 in paraffin-embedded human colon carcinoma tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with Erlin-2 Monoclonal antibody (Product # MA5-44911) using a dilution of 1:50 for 30 ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-44911
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE57-03
抗原
Recombinant protein within human Erlin-2 aa 50-200 (Lumenal).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: endoplasmic reticulum lipid raft-associated protein 2; epididymis secretory sperm binding protein; HGNC:1356; MGC87072; spastic paraplegia 18 (autosomal dominant); SPFH domain family, member 2; SPFH domain-containing protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; unnamed protein product; UNQ2441
基因别名: C8orf2; Erlin-2; NET32; SPFH2; SPG18; SPG18A; SPG18B
UniProt ID: (Human) O94905, (Mouse) Q8BFZ9
Entrez Gene ID: (Human) 11160, (Mouse) 244373
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