Search Thermo Fisher Scientific
ERN2 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 2 protein is a human homologue of the yeast Ire1 gene product which plays a role in multiple facets of the ER stress response in mammalian cells. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Endoplasmic reticulum-to-nucleus signaling 2; ern2; inositol-requiring 1 (Yeast homologue); inositol-requiring 1 beta; Inositol-requiring protein 2; Ire1-beta; IRE1b; mIre1; Serine/threonine-protein kinase/endoribonuclease IRE2
基因别名: Ern1; Ern2; Ire1; Ire1b; Ire2
UniProt ID: (Mouse) Q9Z2E3
Entrez Gene ID: (Mouse) 26918
分子生物学功能: endoribonuclease