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Invitrogen
ETV6 Polyclonal Antibody
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ETV6 Antibody (PA5-90606) in WB
Western blot analysis of ETV6 in extracts of various cell lines. Samples were incubated with ETV6 Polyclonal antibody (Product # PA5-90606) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-90606
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ETV6 (NP_0019781)
偶联物
形式
Liquid
浓度
2.04 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MSETPAQCSI KQERISYTPP ESPVPSYASS TPLHVPVPRA LRMEEDSIRL PAHLRLQPIY WSRDDVAQWL KWAENEFSLR PIDSNTFEMN GKALLLLTKE DFRYRSPHSG DVLYELLQHI LKQRKPRILF SPFFHPGNSI HTQPEVILHQ NHEEDNCVQR TPRPSVDNVH HNPPTIELLH RSRSPITTNH RPSPDPEQRP LRSPLDNMIR RLSPAERAQG PRPHQENNHQ ESYPLSVSPM ENNHCPASSE SHPKPSSPRQ ESTRVIQLMP SPIMHPLILN PRHSVDFKQS RLSEDGLHRE; Positive Samples: HepG2, Mouse lung, Mouse spleen, Rat testis; Cellular Location: Nucleus
靶标信息
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and Maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CGI-108; CSL4; Csl4p; ETS translocation variant 6; ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; hCsl4p; p13; RP11-452K12.9; SKI4; Ski4p; Tel; TEL1 oncogene; Transcription factor ETV6
基因别名: AW123102; AW557856; ETV6; TEL; TEL/ABL; TEL1; THC5
UniProt ID: (Human) P41212, (Mouse) P97360
Entrez Gene ID: (Human) 2120, (Mouse) 14011, (Rat) 312777
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein domain specific binding
DNA binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cell differentiation
positive regulation of transcription from RNA polymerase II promoter
hematopoietic stem cell proliferation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
