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Invitrogen
EWSR1 Polyclonal Antibody
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EWSR1 Antibody (PA5-79225) in ICC/IF
Immunocytochemistry analysis of EWSR1 using anti-EWSR1 antibody (Product # PA5-79225) . EWSR1 was detected in a section of U2OS cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum and then incubated with 2μg/mL rabbit anti-EWSR1 antibody (Product # PA5-79225) overnight at 4°C. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. Visualize using a fluorescence microscope a... View More
产品信息
PA5-79225
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence in the middle region of human EWSR1 (369-399aa NDSVTLDDLADFFKQCGVVKMNKRTGQPMIH).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human K562 whole cell, human Jurkat whole cell, human HL-60 whole cell, human HEK293 whole cell. IHC: Mouse Testis tissue, Rat Testis tissue, Human Mammary Cancer tissue IHC-F: mouse intestine tissue, rat intestine tissue, human placenta tissue. ICC/IF: U20S cell, human SMMC-7721 cell. Flow: U20S cell.
靶标信息
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a ttranslocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AC002059.7; Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 1 protein; Ewing sarcoma homolog; Ewings sarcoma EWS-Fli1 (type 1) oncogene; EWS oncogene; EWS RNA-binding protein 1; EWS RNA-binding protein variant 6; RNA-binding protein EWS
基因别名: bK984G1.4; EWS; EWS-FLI1; Ewsh; EWSR1
UniProt ID: (Human) Q01844, (Mouse) Q61545
Entrez Gene ID: (Human) 2130, (Mouse) 14030, (Rat) 289752
