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Invitrogen
EXD1 Monoclonal Antibody (OTI2G5)
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产品信息
MA5-25350
产品规格
种属反应
Human,
Non-human primate,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI2G5
抗原
Full length human recombinant protein of EXD1 produced in HEK293T cell
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
EXD1 is an RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Exonuclease 3'-5' domain-containing protein 1; exonuclease 3'-5' domain-like 1; Exonuclease 3'-5' domain-like-containing protein 1; Inactive exonuclease EXD1; piRNA biogenesis protein EXD1
基因别名: EXD1; EXDL1; RGD1561009
UniProt ID: (Human) Q8NHP7
Entrez Gene ID: (Human) 161829, (Rat) 311334
