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Abnova
EXDL1 Polyclonal Antibody, MaxPab™
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产品信息
H00161829-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
EXDL1 (NP_689809, 1 a.a. approximately 514 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEDSEFLAYV ELLDEVEQGS VRAKASSVSL HAERTWMEKM KVEDLNVCEP ASPAPEAPAT SLLNDLKYSP SEEEEVTYTV INQFQQKFGA AILHIKKQNV LSVAAEGANV CRHGKLCWLQ VATNCRVYLF DIFLLGSRAF HNGLQMILED KRILKVIHDC RWLSDCLSHQ YGILLNNVFD TQVADVLQFS METGGYLPNC ITTLQESLIK HLQVAPKYLS FLEKRQKLIQ ENPEVWFIRP VSPSLLKILA LEATYLLPLR LALLDEMMSD LTTLVDGYLN TYREGSADRL GGTEPTCMEL PEELLQLKDF QKQRREKAAR EYRVNAQGLL IRTVLQPKKL VTETAGKEEK VKGFLFGKNF RIDKAPSFTS QDFHGDVNLL KEESLNKQAT NPQHLPPTEE GETSEDSSNK LICTKSKGSE DQRITQKEHF MTPKHEFQAS LSLKEETEQL LMVENKEDLK CTKQAVSMSS FPQETRVSPS DTFYPIRKTV VSTLPPCPAL EKIDSWISPF LNLP
靶标信息
EXD1 is an RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Exonuclease 3'-5' domain-containing protein 1; Exonuclease 3'-5' domain-like-containing protein 1; Inactive exonuclease EXD1; piRNA biogenesis protein EXD1
基因别名: EXD1; EXDL1
UniProt ID: (Human) Q8NHP7
Entrez Gene ID: (Human) 161829
