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Invitrogen
EXOSC10 Polyclonal Antibody
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Product Details
PA5-28672
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human EXOSC10. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.65 mg/mL
Amount
65 µg
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, EXOSC10-transfected 293T.
Predicted reactivity: Chimpanzee (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: autoantigen PM-SCL; Autoantigen PM/Scl 2; Exosome complex component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-100; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2; unnamed protein product
Gene Aliases: EXOSC10; p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p
UniProt ID: (Human) Q01780
Entrez Gene ID: (Human) 5394
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
maturation of 5.8S rRNA
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
nuclear-transcribed mRNA catabolic process
nucleobase-containing compound metabolic process
DNA repair
rRNA processing
RNA processing
RNA catabolic process
cellular response to DNA damage stimulus
regulation of gene expression
regulation of nucleobase-containing compound metabolic process
negative regulation of telomere maintenance via telomerase
ribosomal small subunit biogenesis
nuclear mRNA surveillance
CUT catabolic process
nuclear polyadenylation-dependent rRNA catabolic process
nuclear polyadenylation-dependent snoRNA catabolic process
nuclear polyadenylation-dependent snRNA catabolic process
nuclear polyadenylation-dependent tRNA catabolic process
nuclear polyadenylation-dependent CUT catabolic process
nuclear polyadenylation-dependent antisense transcript catabolic process
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
regulation of telomerase RNA localization to Cajal body
positive regulation of mRNA cis splicing, via spliceosome
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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