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EXOSC10 Monoclonal Antibody (1E6)
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产品信息
H00005394-M08
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1E6
抗原
EXOSC10 (NP_001001998.1, 1 a.a. approximately 99 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MAPPSTREPR VLSATSATKS DGEMVLPGFP DADSFVKFAL GSVVAVTKAS GGLPQFGDEY DFYRSFPGFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKD
靶标信息
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: autoantigen PM-SCL; Autoantigen PM/Scl 2; Exosome complex component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-100; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2; unnamed protein product
基因别名: EXOSC10; p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p
UniProt ID: (Human) Q01780
Entrez Gene ID: (Human) 5394
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
maturation of 5.8S rRNA
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
nuclear-transcribed mRNA catabolic process
nucleobase-containing compound metabolic process
DNA repair
rRNA processing
RNA processing
RNA catabolic process
cellular response to DNA damage stimulus
regulation of gene expression
regulation of nucleobase-containing compound metabolic process
negative regulation of telomere maintenance via telomerase
ribosomal small subunit biogenesis
nuclear mRNA surveillance
CUT catabolic process
nuclear polyadenylation-dependent rRNA catabolic process
nuclear polyadenylation-dependent snoRNA catabolic process
nuclear polyadenylation-dependent snRNA catabolic process
nuclear polyadenylation-dependent tRNA catabolic process
nuclear polyadenylation-dependent CUT catabolic process
nuclear polyadenylation-dependent antisense transcript catabolic process
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
regulation of telomerase RNA localization to Cajal body
positive regulation of mRNA cis splicing, via spliceosome
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