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Invitrogen
Ebdarokimab Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA5-59263
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Ebdarokimab, also known as AK101, is a monoclonal antibody that targets interleukin-12 (IL-12) and interleukin-23 (IL-23), two cytokines implicated in the inflammatory response associated with plaque psoriasis. Interleukin-12 subunit beta (IL-12b), also known as IL-12p40, is a crucial component of the heterodimeric cytokine IL-12 and IL-23. The IL-12b gene is located on chromosome 5q31-33 and encodes for a 40 kDa protein. IL-12 is composed of two subunits, p35 and p40, while IL-23 is composed of p19 and the shared p40 subunit. The IL-12b protein has a four-helix bundle structure, homologous to other members of the hematopoietin superfamily. Functionally, IL-12b plays a significant role in immune responses by promoting the differentiation of naive T cells into Th1 cells and enhancing the cytotoxic activity of natural killer (NK) cells. It is essential in the immune system's response to intracellular pathogens. Dysregulation of IL-12b has been implicated in various autoimmune diseases and cancers, making it a target for therapeutic interventions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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