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Invitrogen
Elastase 3A/3B Recombinant Rabbit Monoclonal Antibody (HL2882)
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Elastase 3A/3B Antibody (MA5-56692) in WB
Western Blot analysis of Elastase 3A/3B using Elastase 3A/3B Recombinant Monoclonal Antibody (Product # MA5-56692). Mouse pancreas and mouse liver tissue extracts (50 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with Elastase 3A/3B antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
MA5-56692
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2882
抗原
Recombinant fragment of human Elastase 3A + Elastase 3B.
偶联物
形式
Liquid
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
Elastase 3, also known as pancreatic elastase 3 or ELA3, is an enzyme encoded by the CELA3A and CELA3B genes in humans. This enzyme is a member of the serine protease family and is primarily produced in the pancreas. Elastase 3 plays a critical role in the digestive process by breaking down proteins into smaller peptides, specifically targeting elastin, a key protein component of connective tissue. It is secreted into the small intestine, where it aids in the efficient digestion of dietary proteins. Elastase 3 has significant clinical relevance as its levels can be measured in stool samples to assess pancreatic function. Low levels of elastase 3 in the stool are indicative of exocrine pancreatic insufficiency (EPI), a condition where the pancreas does not produce enough digestive enzymes, leading to malabsorption and nutrient deficiencies. This enzyme is also of interest in research related to various gastrointestinal disorders and pancreatic diseases, including chronic pancreatitis and pancreatic cancer. Understanding the function and regulation of elastase 3 is essential for the development of diagnostic tools and therapeutic strategies for these conditions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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