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Invitrogen
Eotaxin-3-like Polyclonal Antibody
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产品信息
PA5-148769
产品规格
种属反应
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant rat CCL26-like/Eotaxin-3-like, Thr24-Trp94
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Eotaxin-3-like, also known as CCL26 (C-C motif chemokine ligand 26), is a member of the eotaxin family of chemokines, which play crucial roles in the immune system by mediating the recruitment and activation of eosinophils. Eotaxin-3-like is primarily expressed in epithelial cells and is upregulated in response to inflammatory signals such as interleukin-4 (IL-4) and interleukin-13 (IL-13). This chemokine binds to the CCR3 receptor on eosinophils, promoting their migration to sites of inflammation or allergic reactions. Eotaxin-3-like is particularly important in conditions such as asthma, allergic rhinitis, and atopic dermatitis, where elevated levels contribute to the accumulation of eosinophils and the resulting inflammatory response. It is also implicated in other diseases characterized by eosinophilic infiltration, such as eosinophilic esophagitis. Understanding the regulation and function of eotaxin-3-like is essential for developing targeted therapies aimed at modulating eosinophilic responses and treating allergic and inflammatory diseases. Research into eotaxin-3-like provides valuable insights into the broader mechanisms of chemokine-mediated immune cell trafficking and its potential as a therapeutic target for controlling eosinophil-related pathologies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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