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Invitrogen
Ephrin B1 Polyclonal Antibody
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Ephrin B1 Antibody (PA5-89907) in WB
Western blot analysis of Ephrin B1 in mouse brain. Samples were incubated with Ephrin B1 Polyclonal antibody (Product # PA5-89907) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
产品信息
PA5-89907
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 259-346 of human EFNB1 (NP_0044201)
偶联物
形式
Liquid
浓度
0.96 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TVLLLKLRKR HRKHTQQRAA ALSLSTLASP KGGSGTAGTE PSDIIIPLRT TENNYCPHYE KVSGDYGHPV YIVQEMPPQS PANIYYKV; Positive Samples: Mouse brain; Cellular Location: Membrane, Single-pass type I membrane protein
靶标信息
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CEK5 receptor ligand; CEK5-L; CEL5-L; EFL-3; EFL6; EFNB3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; Ephrin B3; Ephrin-B1; Ephrin-B1 precursor; EphrinB1; EPLG8; kinase ephrin-B1; LERK-2; LERK8; Stimulated by retinoic acid gene 1 protein; STRA1 protein
基因别名: Cek5-L; EFL-3; Efnb1; Elk-L; Epl2; Eplg2; LERK-2; Lerk2; Stra1
UniProt ID: (Mouse) P52795
Entrez Gene ID: (Mouse) 13641
