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Invitrogen
Epstein Barr Virus LMP2A Monoclonal Antibody (15F9)
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Epstein Barr Virus LMP2A Antibody (MA1-81921) in WB
PLoS pathogens 2022 -
10.1371/journal.ppat.1010200.g001 Fig 1 LMP1 expression is associated with CCL17 and CCL22 production. (A) Western blots on 50 mug of protein lysate from 9 human cell lines were probed for LMP1 and LMP2A. Supernatants from these cell lines were assayed by ELISA for CCL17 and CCL22 protein. Chemokines were measured in biological duplicates with error bars at +- 1SD. Westerns were quantitated by densitometry ... View More
产品信息
MA1-81921
产品规格
种属反应
Virus
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
15F9
抗原
Bacterial TrpE-LMP2A fusion protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections.
Rat anti Epstein-Barr Virus LMP2A antibody, clone 15F9 recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV).
靶标信息
Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
