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ErbB2 (HER-2) Polyclonal Antibody

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ErbB2 (HER-2) Polyclonal Antibody

产品信息

PA5-115351

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human ERBB2(Accession P04626), corresponding to amino acid residues Y1222-V1255.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Affinity chromatography

保存液

PBS with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2899987

产品详细信息

Antibody detects endogenous levels of total HER2/ErbB2.

靶标信息

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: approximately 68 kDa secreted autoinhibitor glycoprotein; avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; erbB2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; metastatic lymph node gene 19 protein; Neu oncogene; neu oncogene; p185; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185 precursor; neu/erbB-2; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; proto-oncogene NEU; receptor tyrosine-protein kinase erbB-2-like; tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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基因别名: c-ERB-2; c-ERB2; c-erbB2; c-neu; CD340; Erbb-2; HER-2; HER-2/neu; HER2; HER2/neu; l11Jus8; mKIAA3023; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2

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UniProt ID: (Human) P04626, (Mouse) P70424

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Entrez Gene ID: (Human) 2064, (Mouse) 13866, (Rat) 24337

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功能
RNA polymerase I core binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity receptor binding protein binding ATP binding coreceptor activity growth factor binding receptor tyrosine kinase binding identical protein binding ErbB-3 class receptor binding protein heterodimerization activity ubiquitin protein ligase binding macromolecular complex binding Hsp90 protein binding
参与通路
signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway nervous system development peripheral nervous system development heart development neuromuscular junction development motor neuron axon guidance cell proliferation positive regulation of cell proliferation glial cell differentiation positive regulation of gene expression Schwann cell development peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of cell growth axon regeneration regulation of microtubule-based process negative regulation of immature T cell proliferation in thymus positive regulation of Rho protein signal transduction intracellular signal transduction ERBB signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-EGFR signaling pathway ERBB2-ERBB4 signaling pathway wound healing regulation of cell proliferation myelination negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling estrous cycle positive regulation of translation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction protein autophosphorylation sympathetic nervous system development animal organ development response to axon injury oligodendrocyte differentiation positive regulation of epithelial cell proliferation positive regulation of small GTPase mediated signal transduction positive regulation of protein kinase B signaling regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus semaphorin-plexin signaling pathway positive regulation of protein targeting to membrane neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of membrane permeability positive regulation of neural precursor cell proliferation liver development skeletal muscle tissue development female pregnancy response to xenobiotic stimulus response to muscle activity response to progesterone response to vitamin D multicellular organismal response to stress tongue development regulation of cell differentiation mammary gland involution cellular response to mechanical stimulus response to dexamethasone protein phosphorylation enzyme linked receptor protein signaling pathway ERBB2 signaling pathway regulation of angiogenesis
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