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Invitrogen
Estrone Recombinant Mouse Monoclonal Antibody (2D9)
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Estrone Antibody (MA566518) in SDS-PAGE
SDS-PAGE characterization of Estrone under reducing conditions. Lane M: Protein marker (kDa); Lane E1: Purified Estrone Recombinant Monoclonal (Product # MA566518). Estrone showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-370.
产品信息
MA566518
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2D9
抗原
Conjugate of E1 hapten and KLH.
偶联物
形式
Liquid
浓度
8.8 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. it is converted from androstenedione directly, or from testosterone via estradiol. In humans, it is produced primarily by the cyclic ovaries, placenta, and the adipose tissue of men and postmenopausal women. Therapeutic estrone is the synthetic form of a naturally occurring estrogen estrone. Estrone diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated hormone-receptor complex gets translocated to the nucleus where it binds to the estrogen response element on the dna and promotes the transcription of target genes involved in the functioning of the female reproductive system and secondary sex characteristics. Estrone increases the hepatic synthesis of sex hormone binding globulin (shbg), thyroid-binding globulin (tbg), and other serum proteins, as well as suppresses the release of follicle-stimulating hormone (fsh) and luteinizing hormone (lh) from the anterior pituitary. [National Center for Biotechnology Information. PubChem Compound Database; CID=5870].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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